Effect of acidification on biological proprieties of sodium carboxymethylcellulose

Main Article Content

Lamia Mansouri
Meriem Elkolli
Bouanane Zohra


Sodium Carboxymethylcellulose (NaCMC) was subjected to an acidification reaction by hydrochloric acid. Characterization and identification of acidified carboxymethylcellulose (HCMC) was made by Fourier transformed Infrared spectroscopy (FT-IR), Elemental analysis (XRF) and Thermal analysis (TGA - DSC). The opacity measurement shows a marked difference in powders structure. The blood-clotting tests demonstrate that HCMC is more hemostatic than NaCMC. Mucoadhesion exhibits a pronounced increase in adhesion times of HCMC contrary to NaCMC on the gastric and intestinal mucosa. Besides, biodegradability is established.

Article Details

How to Cite
Mansouri, L., Elkolli, M., & Zohra, B. (2020). Effect of acidification on biological proprieties of sodium carboxymethylcellulose. Materials and Biomaterials Science, 3(2), 065–070. Retrieved from http://www.mbmscience.com/index.php/mbms/article/view/33
Original Paper


Zohuriaan MJ, Shokrolahi F. Thermal studies on natural and modified gums. Polymer Testing 2004; 23: 575–579.

Jiang X, Yang Z, Peng Y, et al. Preparation , characterization and feasibility study of dialdehyde carboxymethyl cellulose as a novel crosslinking reagent. Carbohydr. Polym 2016; 137: 632–641.

Liuyun J, Yubao L, Chengdong X. tissue engineering. Pre- paration and biological properties of a novel composite scaffold of nano-hydroxyapatite/chitosan/carboxymethyl cellulose for bone tissue engineering. Journal of Biomedical Science 2009; 16(1): 65.

Sathiyanarayanan P, Karunakaran RJ, Gomathi T, et al. Synthesis and characterization of carboxymethyl cellulose / polyethylene glycol / montmorillonite clay blends. International Journal Of Novel Trends In Pharmaceutical Sciences 2015; 5 : 36–41.

Bao Y, Ma J, Li N. Synthesis and swelling behaviors of sodium carboxymethyl cellulose-g-poly ( AA-co-AM-co-AMPS )/ MMT superabsorbent hydrogel. Carbohydr. Polym. 2011; 84: 76–82.

Casaburi A, Rojo ÚM, Cerrutti P, Vázquez A, Foresti L. Carboxymethyl cellulose with tailored degree of substi- tution obtained from bacterial cellulose. Food Hydrocol- loids 2017; 75: 147-156.

Roshan KR, Mathai G, Kim J, et al. A biopolymer media- ted efficient synthesis of cyclic carbonates from epoxides and carbon dioxide. Green Chem 2012; 14: 2933.

Biswal DR, Singh RP. Characterisation of carboxymethyl cellulose and polyacrylamide graft copolymer. Carbohydr Polym 2004; 57: 379–387.

Li H, Wu B, Mu C, et al. Concomitant degradation in periodate oxidation of carboxymethyl cellulose. Carbohydr Polym 2011; 84: 881–886.

Tunç S, Duman O. Applied Clay Science Preparation and characterization of biodegradable methyl cellulose / montmorillonite nanocomposite fi lms. Applied Clay Science 2010; 48: 414–424.

Zhao Q, Xi WÆ, Chen G, et al. Preparation and blood coagulation evaluation of chitosan microspheres. Journal of Materials Science 2008; 19: 1371–1377.

Cerchiara T, Abruzzo A, Parolin C, et al. Microparticles based on chitosan/carboxymethylcellulose polyelectrolyte complexes for colon delivery of vancomycin. Carbo- hydr Polym 2016; 143: 124–130.

Agarwal T, Narayana SNGH, Pal K, et al. Calcium alginate-carboxymethyl cellulose beads for colontargeted drug delivery. Int J Biol Macromol 2015; 75: 409–417.

Barbeck M, Serra T, Booms P, et al. Analysis of the in vitro degradation and the in vivo tissue response to bilayered 3D-printed scaffolds combining PLA and biphasic PLA/bioglass components – Guidance of the inflamma- tory response as basis for osteochondral regeneration. Bioact Mater 2017; 1–16.

Muzzarelli RAA, Tanfani F, Emanuelli M, et al. N- (carboxymethylidene) chitosans and N-(carboxymethyl) chitosans: Novel chelating polyampholytes obtained from chitosan glyoxylate. Carbohydr Res 1982; 107: 199–214.

Ren JL, Sun RC, Peng F. Carboxymethylation of hemicel- luloses isolated from sugarcane bagasse. Polym Degrad Stab 2008; 93: 786–793.

Robert M. Silverstein, Francis X. Webster DJK. Spectro- metric identification of organic compounds. John Wiley & Sons, New York, 2005.

Duhoranimana E, Karangwa E, Lai L, et al. Food Hydrocolloids Effect of sodium carboxymethyl cellulose on complex coacervates formation with gelatin : Coacervates characterization , stabilization and formation mechanism. Food Hydrocolloids 2017; 69: 111–120.

Regiani A, Pawlicka A. Carboxymethylcellulose derivatives with low hydrophilic properties. Polimery 2003; 48: 273–279.

El-sayed S, Mahmoud KH, Fatah AA, et al. DSC , TGA and dielectric properties of carboxymethyl cellulose / polyvinyl alcohol blends. Phys B Phys Condens Matter 2011; 406: 4068–4076.

Tranquilan-aranilla C, D BJ, Vista JRM, et al. Accepted Manuscript. Radiat Phys Chem. 2016; 124: 124–129.

Taaca KLM, Vasquez, MRV. Hemocompatibility and cyto- compatibility of pristine and plasma-treated silver-zeo- lite-chitosan composites. Applied Surface Science 2017; 432 : 324–321.

Fan L, Yang H, Yang J, et al. Preparation and characterization of chitosan/gelatin/PVA hydrogel for wound dressings. Carbohydr Polym. 2016. DOI: 10.1016/j.carb- pol.2016.03.002.

Michael J. Rathbone, Sevda Senel IP. Oral Mucosal Drug Delivery and Therapy. 2015 (1st ed.). US: Springer, (Chap- ter 4). DOI: 10.1007/978-1-4899-7558-4.

Pritchard K, Lansley AB, Martin GP, et al. Evaluation of the bioadhesive properties of hyaluronan derivatives : detachment weight and mucociliary transport rate. Inter- national Journal of Pharrnaceutics 1996; 129: 137-145.

Madsen F, Eberth K, Smart JD. A rheological examination of the mucoadhesive / mucus interaction : the effect of mucoadhesive type and concentration. Journal of Control- led Release 1998; 50: 167–178.